When you have an injury or surgery, your body creates pain signals that travel through your nervous system to the brain. It’s not until the brain receives these signals that you feel pain.
Watch to learn more about how JOURNAVX works
Watch to learn more about how JOURNAVX works
Watch to learn more about how JOURNAVX works
JOURNAVX is a pain signal inhibitor that reduces pain signals before they reach the brain and are felt as pain.
Voiceover:
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Signals run the world—from our phones to our screens, from stoplights to satellites and everything in between. Signals surround us wherever we go. Even pain is determined by signals, did you know? When something happens that leaves you hurt, your body makes pain signals to spread the alert.
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They move through your nerves with incredible speed, ‘til they get to the brain where pain is perceived. But what if those signals couldn't get through? Well, that's what JOURNAVX was created to do. When pain signals start, JOURNAVX steps in, and decreases those signals where they begin.
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It's a nonopioid that works in one of the channels called NaV , which are a part of the nerves that all of us have. Pain signals are reduced before they reach your brain. And when they don't get there, you feel less pain.
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Changing the signals’ journey, changes yours too. So in the end, pain can become less painful for you. JOURNAVXTM (suzetrigine) is a nonopioid medication used to treat adults with moderate-to-severe acute pain.
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Where Pain Starts JOURNAVX BeginsTM . Ask your doctor about JOURNAVX.
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What is JOURNAVX?
JOURNAVX is a prescription medicine used to treat adults with moderate-to-severe short-term (acute) pain.
It is not known if JOURNAVX is safe and effective in children.
IMPORTANT SAFETY INFORMATION
Do not take JOURNAVX if you take certain medicines that are strong inhibitors of an enzyme called CYP3A. Ask your healthcare provider if you are not sure.
Before taking JOURNAVX, tell your healthcare provider about all of your medical conditions, including if you:
- have liver problems. People with liver problems may have an increased risk of getting side effects from taking JOURNAVX
- are pregnant or plan to become pregnant. It is not known if JOURNAVX will harm your unborn baby. You and your healthcare provider should decide if you will take JOURNAVX while you are pregnant
- are breastfeeding or planning to breastfeed. It is not known if JOURNAVX passes into your breast milk. You and your healthcare provider should decide if you will take JOURNAVX while you are breastfeeding
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Taking JOURNAVX with certain other medicines may affect the way JOURNAVX and the other medicines work and may increase your risk of side effects. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.
Especially tell your healthcare provider if you take:
- hormonal birth control medicine (contraceptives) containing progestins other than levonorgestrel or norethindrone. If you take one of these contraceptives (progestins other than levonorgestrel or norethindrone), they may not work as well during treatment with JOURNAVX. You should also use nonhormonal contraceptives such as condoms or use other forms of hormonal birth control during treatment with JOURNAVX and for 28 days after you stop taking JOURNAVX
- medicines that are substrates of the CYP3A enzyme as they may become less effective during treatment with JOURNAVX. Your healthcare provider may need to adjust the dose of your medicine when starting or stopping JOURNAVX
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
What should I avoid while taking JOURNAVX?
Do not take food or drink containing grapefruit during treatment with JOURNAVX.
What are the possible side effects of JOURNAVX?
The most common side effects for patients treated with JOURNAVX included itching, muscle spasms, increased blood level of creatine phosphokinase, and rash.
JOURNAVX may temporarily reduce the chance of females becoming pregnant while on treatment. Talk to your healthcare provider if you have concerns about becoming pregnant. If you are using contraceptives, you should continue to use contraceptives during treatment with JOURNAVX.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all of the possible side effects of JOURNAVX.
Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Please see full Prescribing Information, including Patient Information, for JOURNAVX.
JOURNAVX is a nonopioid medicine that works in the peripheral nervous system
- The peripheral nervous system is the part of your nervous system that lies outside your brain and spinal cord; it sends information throughout your body to and from your brain
- JOURNAVX targets a specific nerve channel in your peripheral nervous system called NaV1.8
- When JOURNAVX targets this specific channel, NaV1.8, pain signals are reduced before they can reach the brain
- JOURNAVX works on NaV1.8, which is not expressed in the brain and is not related to addiction
- JOURNAVX doesn't affect other tissues in your body outside of your peripheral nervous system
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Interested in JOURNAVX?
Download our doctor conversation guide to help you be prepared for conversations with your doctor about JOURNAVX.
What is JOURNAVX?
JOURNAVX is a prescription medicine used to treat adults with moderate-to-severe short-term (acute) pain.
It is not known if JOURNAVX is safe and effective in children.
IMPORTANT SAFETY INFORMATION
Do not take JOURNAVX if you take certain medicines that are strong inhibitors of an enzyme called CYP3A. Ask your healthcare provider if you are not sure.
Before taking JOURNAVX, tell your healthcare provider about all of your medical conditions, including if you:
What is JOURNAVX?
JOURNAVX is a prescription medicine used to treat adults with moderate-to-severe short-term (acute) pain.
It is not known if JOURNAVX is safe and effective in children.
IMPORTANT SAFETY INFORMATION
Do not take JOURNAVX if you take certain medicines that are strong inhibitors of an enzyme called CYP3A. Ask your healthcare provider if you are not sure.
Before taking JOURNAVX, tell your healthcare provider about all of your medical conditions, including if you:
- have liver problems. People with liver problems may have an increased risk of getting side effects from taking JOURNAVX
- are pregnant or plan to become pregnant. It is not known if JOURNAVX will harm your unborn baby. You and your healthcare provider should decide if you will take JOURNAVX while you are pregnant
- are breastfeeding or planning to breastfeed. It is not known if JOURNAVX passes into your breast milk. You and your healthcare provider should decide if you will take JOURNAVX while you are breastfeeding
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Taking JOURNAVX with certain other medicines may affect the way JOURNAVX and the other medicines work and may increase your risk of side effects. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.
Especially tell your healthcare provider if you take:
- hormonal birth control medicine (contraceptives) containing progestins other than levonorgestrel or norethindrone. If you take one of these contraceptives (progestins other than levonorgestrel or norethindrone), they may not work as well during treatment with JOURNAVX. You should also use nonhormonal contraceptives such as condoms or use other forms of hormonal birth control during treatment with JOURNAVX and for 28 days after you stop taking JOURNAVX
- medicines that are substrates of the CYP3A enzyme as they may become less effective during treatment with JOURNAVX. Your healthcare provider may need to adjust the dose of your medicine when starting or stopping JOURNAVX
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
What should I avoid while taking JOURNAVX?
Do not take food or drink containing grapefruit during treatment with JOURNAVX.
What are the possible side effects of JOURNAVX?
The most common side effects for patients treated with JOURNAVX included itching, muscle spasms, increased blood level of creatine phosphokinase, and rash.
JOURNAVX may temporarily reduce the chance of females becoming pregnant while on treatment. Talk to your healthcare provider if you have concerns about becoming pregnant. If you are using contraceptives, you should continue to use contraceptives during treatment with JOURNAVX.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all of the possible side effects of JOURNAVX.
Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Please see full Prescribing Information, including Patient Information, for JOURNAVX.