If you’re considering JOURNAVX, you might have some questions. Here you’ll find information about JOURNAVX, acute pain, dosing, and other related questions.
Talk to your doctor if you have questions.
About acute pain
What is acute pain?
Acute pain is a type of pain that starts suddenly and lasts less than 3 months. It often happens because of an injury or surgery.
How does pain work?
When you have an injury or surgery, your body creates pain signals that travel through your nerves to your brain. It's not until the brain receives these signals that you feel pain.
About JOURNAVX
What is JOURNAVX?
JOURNAVX is a prescription medicine used to treat adults with moderate to severe short-term (acute) pain.
How does JOURNAVX work?
- When you have an injury or surgery, your body creates pain signals that travel through nerves from the site of pain to your brain. Only when the brain receives these signals do you feel pain.
- JOURNAVX is a pain signal inhibitor—it helps reduce pain signals before they reach the brain, reducing the pain you feel. JOURNAVX targets a specific channel, called NaV1.8, in your peripheral nervous system that pain signals travel through.
What were the results with JOURNAVX in clinical trials?
- JOURNAVX was proven to be effective in 2 clinical studies, which led to its approval by the FDA for the treatment of moderate-to-severe acute pain in adults.
- JOURNAVX demonstrated superior pain relief over placebo.
- JOURNAVX was not better at reducing pain than hydrocodone/ acetaminophen.
Learn more about the results with JOURNAVX.
See the safety profile of JOURNAVX.
What are the most common side effects with JOURNAVX?
- The most common side effects with JOURNAVX include itching, muscle spasms, increase in a certain blood enzyme called creatine phosphokinase, and rash.
Learn more about the safety profile of JOURNAVX.
How was JOURNAVX studied?
- JOURNAVX demonstrated superior pain relief over placebo in two Phase 3 clinical trials.
- These trials included over 2000 adults from various ages, genders, and racial backgrounds.
- Each participant was experiencing moderate-to-severe acute pain from either a tummy tuck or bunion removal.
- The efficacy and safety of JOURNAVX were tested against a placebo and a combination of hydrocodone (a commonly prescribed opioid) and acetaminophen.
- People were randomly selected to receive either JOURNAVX, placebo, or hydrocodone/acetaminophen for 48 hours following surgery.
Learn more about the study design.
Does JOURNAVX have addictive potential?
- There is no evidence that JOURNAVX has addictive potential based on available data, which includes the way JOURNAVX works in the body, as well as preclinical data and clinical data about side effects.
- JOURNAVX targets a specific protein called NaV1.8 that does not exist in the human brain and is not related to addiction.
Learn more about how JOURNAVX works.
Taking JOURNAVX
What is the dosing for JOURNAVX and how do I take it?
- For the first dose, take two JOURNAVX tablets by mouth, at least 1 hour before or 2 hours after food. During this time, clear liquids may be consumed (such as water, apple juice, vegetable broth, tea, or black coffee).
- After your first dose, take one JOURNAVX tablet by mouth 12 hours after the first dose, then every 12 hours for as long as your doctor recommends. These can be taken with or without food.
- For every dose, swallow tablets whole. Do not chew or crush the tablets.
What should I do if I miss a dose?
If you miss one dose:
- Take the missed dose as soon as you can. Then take your next scheduled dose.
If you miss two or more doses:
- Take two JOURNAVX tablets. Then take your next scheduled dose.
If you miss a dose and have liver problems or take moderate inhibitors of CYP3A:
- Your dosing schedule may be different. Talk to your doctor or pharmacist.
If you are not sure about your dosing, ask your doctor or pharmacist.
Can I use other medicines with JOURNAVX?
- Some medicines may affect how JOURNAVX works, or JOURNAVX may impact the function of other medications.
- Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
- Consult your doctor about your specific situation and condition to see if JOURNAVX could be right for you.
- Your doctor may provide different instructions based on your situation. Take JOURNAVX exactly as your doctor tells you to take it.
- Especially tell your healthcare provider if you take:
- hormonal birth control medicine (contraceptives) containing progestins other than levonorgestrel or norethindrone. If you take one of these contraceptives (progestins other than levonorgestrel or norethindrone), they may not work as well during treatment with JOURNAVX. You should also use nonhormonal contraceptives such as condoms or use other forms of hormonal birth control during treatment with JOURNAVX and for 28 days after you stop taking JOURNAVX
- medicines that are substrates of the CYP3A enzyme as they may become less effective during treatment with JOURNAVX. Your healthcare provider may need to adjust the dose of your medicine when starting or stopping JOURNAVX
- You can also visit the Taking JOURNAVX page for additional information.
What should I avoid eating or drinking while taking JOURNAVX?
- Avoid eating grapefruit and food or drink containing grapefruit while you're taking JOURNAVX because they may affect the amount of JOURNAVX in your body or how your body processes JOURNAVX.
- Take your first dose of JOURNAVX on an empty stomach at least 1 hour before or 2 hours after food. During this time, clear liquids may be consumed (such as water, apple juice, vegetable broth, tea, or black coffee).
- From the second dose on, JOURNAVX can be taken with or without food.
Can I take JOURNAVX if I'm pregnant, planning to become pregnant, or breastfeeding?
- Talk to your doctor if you have questions about JOURNAVX relating to pregnancy, nursing, or fertility.
- It is not known if JOURNAVX will harm your unborn baby or if JOURNAVX passes into your breast milk. You and your healthcare provider should decide if you will take JOURNAVX while you are pregnant or breastfeeding.
Should I tell my doctor if I have certain medical conditions?
Before taking JOURNAVX, tell your doctor about all of your medical conditions, including if you:
- have liver problems
- are pregnant or plan to become pregnant
- are breastfeeding or plan to breastfeed
Can I take JOURNAVX if I’m taking other medications?
Tell your doctor about all the medicines you take, especially if you take hormonal birth control, medicines that are substrates of an enzyme called CYP3A, or if you have liver problems, as dosing instructions may vary.
Do not take JOURNAVX if you take certain medicines that are strong inhibitors of an enzyme called CYP3A. Ask your doctor if you're not sure.
Savings and support
What is JOURNAVX+youᵀᴹ ?
The JOURNAVX+you Patient Support Program provides resources and support to help you get started with JOURNAVX.
JOURNAVX+you includes the following offerings:
- Financial support programs for patients with and without insurance
- JOURNAVX+you Specialists for support and information about program offerings
- Downloadable educational resources
Learn more about the Patient Support Program.
What financial support options are available?
There are financial support programs available to help reduce patient out-of-pocket costs for JOURNAVX.
A JOURNAVX Savings Card is available for eligible patients. Learn more at JOURNAVX.com/support.
If you are uninsured, you may be eligible to participate in the Patient Assistance program. Visit JOURNAVXpap.com for more information.
Where is JOURNAVX Available?
JOURNAVX is available at major national and select regional retail pharmacies. Product availability at individual stores may vary. Please check with your preferred retail pharmacy to see if they carry JOURNAVX.
What is JOURNAVX?
JOURNAVX is a prescription medicine used to treat adults with moderate-to-severe short-term (acute) pain.
It is not known if JOURNAVX is safe and effective in children.
IMPORTANT SAFETY INFORMATION
Do not take JOURNAVX if you take certain medicines that are strong inhibitors of an enzyme called CYP3A. Ask your healthcare provider if you are not sure.
Before taking JOURNAVX, tell your healthcare provider about all of your medical conditions, including if you:
What is JOURNAVX?
JOURNAVX is a prescription medicine used to treat adults with moderate-to-severe short-term (acute) pain.
It is not known if JOURNAVX is safe and effective in children.
IMPORTANT SAFETY INFORMATION
Do not take JOURNAVX if you take certain medicines that are strong inhibitors of an enzyme called CYP3A. Ask your healthcare provider if you are not sure.
Before taking JOURNAVX, tell your healthcare provider about all of your medical conditions, including if you:
- have liver problems. People with liver problems may have an increased risk of getting side effects from taking JOURNAVX
- are pregnant or plan to become pregnant. It is not known if JOURNAVX will harm your unborn baby. You and your healthcare provider should decide if you will take JOURNAVX while you are pregnant
- are breastfeeding or planning to breastfeed. It is not known if JOURNAVX passes into your breast milk. You and your healthcare provider should decide if you will take JOURNAVX while you are breastfeeding
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Taking JOURNAVX with certain other medicines may affect the way JOURNAVX and the other medicines work and may increase your risk of side effects. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.
Especially tell your healthcare provider if you take:
- hormonal birth control medicine (contraceptives) containing progestins other than levonorgestrel or norethindrone. If you take one of these contraceptives (progestins other than levonorgestrel or norethindrone), they may not work as well during treatment with JOURNAVX. You should also use nonhormonal contraceptives such as condoms or use other forms of hormonal birth control during treatment with JOURNAVX and for 28 days after you stop taking JOURNAVX
- medicines that are substrates of the CYP3A enzyme as they may become less effective during treatment with JOURNAVX. Your healthcare provider may need to adjust the dose of your medicine when starting or stopping JOURNAVX
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
What should I avoid while taking JOURNAVX?
Do not take food or drink containing grapefruit during treatment with JOURNAVX.
What are the possible side effects of JOURNAVX?
The most common side effects for patients treated with JOURNAVX included itching, muscle spasms, increased blood level of creatine phosphokinase, and rash.
JOURNAVX may temporarily reduce the chance of females becoming pregnant while on treatment. Talk to your healthcare provider if you have concerns about becoming pregnant. If you are using contraceptives, you should continue to use contraceptives during treatment with JOURNAVX.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all of the possible side effects of JOURNAVX.
Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Please see full Prescribing Information, including Patient Information, for JOURNAVX.